Test Drive

Nutanix NCI 7.3 Enhancements Include Support for AMD’s 5th Generation EPYC™ Processors

By Vish Mulchand, Sr. Director, Product Management

October 1, 2025 8:48 am |
min

Our team is excited to share that the latest release of Nutanix Cloud Infrastructure (NCI) 7.3 software introduces a new wave of platform-level enhancements. With key improvements in multicluster operations, disaster recovery, performance, and scaling, NCI 7.3  helps run modern workloads more efficiently across core, cloud, and edge.

The Right Platform for What’s Next

Nutanix Cloud Infrastructure (NCI) 7.3 strengthens the foundation that powers the Nutanix Cloud Platform (NCP) solution with:

  • Improved multicluster operations: New global dashboards, unified views, and simplified upgrades make it easier to manage large, distributed environments.
  • Stronger disaster recovery: Enhanced replication, more granular RPO/RTO options, and streamlined failover workflows help protect mission-critical workloads.
  • Performance and scale enhancements: Updates to core storage and networking services unlock faster I/O, improved scalability, and better throughput for demanding applications.

Learn more about the enhancements delivered in NCI 7.3.

These improvements arrive alongside another major milestone: support for AMD’s 5th Generation EPYC™ 9005 Series processors, based on the new Zen 5 architecture. NCI 7.3 makes it easy for customers to harness the full performance potential of next-gen hardware within an operational model that Nutanix customers trust, whether they’re scaling out, consolidating infrastructure, or modernizing critical workloads.

Powering More Efficient Modern Data Centers

AMD’s 9005 Series enables customers to minimize their server footprint and is directing  the industry towards increased single-socket server deployments, allowing customers to have a large number of high-performance cores in a power-efficient platform. This enables customers to be energy efficient and consolidate servers in rack dense configurations. Nutanix customers realize infrastructure cost benefits, high performance, cluster resiliency, and potential per-socket license savings with high VM density per server.1

  • Minimize NUMA latency and boost memory/cache efficiency
  • Designed for lower power demand, high CPU core counts with improved power and thermal thresholds
  • Potential per socket application license savings

Architecture Enhancements for High Performance Workloads

The AMD EPYC 9005 Series uses a hybrid, multi-chip design with new ‘Zen 5’ and ‘Zen 5c’ cores. These processors deliver significant improvements in compute density, memory performance, and latency, ideal for enterprises running AI, edge analytics, and other demanding workloads. 

Compared to the previous generation, EPYC 9005 Series processors offer up to 17% higher instructions per clock (IPC) for general-purpose workloads and up to 37% IPC gains for AI and analytics applications.2

These performance gains are driven by architectural enhancements including:

  • Over 128 cores per socket, enabling dense workload consolidation
  • 12 DDR5 memory channels per CPU, supporting speeds up to DDR5-6400 MT/s
  • 1MB of L2 cache per core, with a shared 32MB L3 cache per die to reduce latency and improve data locality

Nutanix AHV hypervisor support extends up to 512 hyper-threads per system, enabling configurations such as the EPYC 9965 (192 cores) in single-socket systems and up to the EPYC 9745 (128 cores per socket) in dual-socket environments.

AMD EPYC 5th Generation support has already been launched for Cisco UCS®, HPE ProLiant® DX, and Lenovo ThinkAgile® HX. Support will be announced in the coming months for: Nutanix NX, Dell XC™ / XC+, and Fujitsu PRIMERGY® XF servers. 

Learn more about Nutanix-supported platforms and review detailed platform specifications with the dynamic spec sheet.

Build a Smarter, More Efficient Datacenter with Nutanix and AMD

With the addition of AMD’s latest EPYC processors, Nutanix NCI 7.3 gives customers even more ways to modernize their infrastructure without compromise.

Whether you're consolidating legacy servers, scaling AI workloads, or deploying cloud-native applications, NCP on AMD delivers performance, security, and efficiency at every layer.

Ready to see it in action?

Take a Nutanix Test Drive and experience the simplicity and performance for yourself.

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[1]Performance varies by use, configuration, and other factors. Learn more from AMD

No product or component can be absolutely secure. Your costs and results may vary.

AMD technologies may require enabled hardware, software, or service activation.

[2] Learn More from AMD

 

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